FRS2 antibody

Catalog No. ABIN7604892

This Rabbit Monoclonal antibody specifically detects FRS2 in WB, IP and FACS. It exhibits reactivity toward Human.

Quick Overview for FRS2 antibody (ABIN7604892)

Target: FRS2 (Fibroblast Growth Factor Receptor Substrate 2 (FRS2))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This FRS2 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Flow Cytometry (FACS)

Clone: ACOG-6

Product Details anti-FRS2 Antibody

Purpose: Anti-FRS2 Monoclonal Antibody

Characteristics: Anti-FRS2 Monoclonal Antibody (ABIN7604892). Tested in WB, IP, Flow Cytometry applications. This antibody reacts with Human.

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human FRS2 Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000
IP 1:50
FC 1:20

Restrictions: For Research Use only

Handling

Format: Liquid

Reconstitution: Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Concentration: Lot specific

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Target Details for FRS2

Target: FRS2 (Fibroblast Growth Factor Receptor Substrate 2 (FRS2))

Alternative Name: FRS2

Background:

Synonyms: Histone-lysine N-methyltransferase SETD7,2.1.1.43,Histone H3-K4 methyltransferase SETD7,H3-K4-HMTase SETD7,Lysine N-methyltransferase 7,SET domain-containing protein 7,SET7/9,SETD7,KIAA1717, KMT7, SET7, SET9,

Tissue Specificity: Widely expressed. Expressed in pancreatic islets.

Molecular Weight: 140 kDa

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Signaling Events mediated by VEGFR1 and VEGFR2